Selection between mitochondrial genomes depends on how each type of mitochondria affects cell metabolism

Thje group of Guadalupe Sabio has participated in a research that has identified the mechanism of competition between distinct mitochondrial genomes coexisting in the same cell. The study, published in Science Advances, examines why the simultaneous presence of more than one variant of mitochondrial DNA (mtDNA) in a cell is rejected in most cells, which select a single mtDNA variant whose identity depends on the tissue.

The study reveals that cells can detect the presence of different mitochondrial genomes and select among them according to their effect on metabolic status.